Growth hormone axis
Ipamorelin
Also known as NNC 26-0161
A pentapeptide growth hormone secretagogue studied for its selectivity relative to earlier compounds in the class.
What it is
Ipamorelin is a five-amino-acid synthetic peptide that acts at the ghrelin receptor. Research interest has centred on selectivity: earlier secretagogues in this class also moved cortisol and prolactin in study models, and ipamorelin was developed and characterised against that problem.
What published research examines
- Ghrelin receptor binding and selectivity profiling
- Growth hormone release patterns in animal models
- Cortisol and prolactin response compared with earlier secretagogues
- Combination research with growth hormone releasing hormone analogues
Where the research stands
Ipamorelin was studied in early-phase human trials by its original developer, though development did not continue for that indication. Most available literature is preclinical.