Cellular and metabolic research
5-Amino-1MQ
Also known as 5-amino-1-methylquinolinium
A small molecule inhibitor of the enzyme NNMT, studied in the context of adipocyte metabolism.
What it is
5-Amino-1MQ is a small molecule rather than a peptide, included here because it appears in the same metabolic research context. It inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that is highly expressed in fat tissue and that consumes nicotinamide, a precursor in the NAD+ salvage pathway.
What published research examines
- NNMT inhibition and its downstream effect on cellular NAD+
- Adipocyte size and lipogenesis in animal models
- Skeletal muscle regeneration in preclinical studies
- Relationship between NNMT expression and metabolic phenotype
Where the research stands
Research on 5-Amino-1MQ is recent and concentrated in cell and animal models. Human data is not yet established.