Cellular and metabolic research
AOD-9604
Also known as hGH fragment 176-191
A modified fragment of human growth hormone, studied for metabolic activity without the growth-promoting effects of the full hormone.
What it is
AOD-9604 corresponds to amino acids 176 to 191 of human growth hormone, the region associated with fat metabolism, with a small structural modification. The research premise is that this fragment separates the metabolic activity of growth hormone from its effects on tissue growth and glucose handling.
What published research examines
- Lipolysis and fat oxidation in animal models
- Whether IGF-1 and blood glucose remain unaffected, a key question in the literature
- Cartilage and joint tissue in exploratory studies
- Receptor interactions distinct from the full growth hormone molecule
Where the research stands
AOD-9604 has been through human trials, with results that did not consistently replicate the effects seen in animal models. It is not approved by the FDA.